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1.发明授权5-methyl-1-(naphthalen-2-yl)-1H-pyrazole derivatives and their use in potentiating the effect of opioid analgesics 有权5-甲基-1-（萘-2-基）-1H-吡唑衍生物及其用于增强阿片类镇痛药的作用公开(公告)号：US08729073B2
公开(公告)日：2014-05-20
申请号：US13991267
申请日：2011-12-02
IPC分类号： A61K31/535 , A61K31/44 , C07D265/30
CPC分类号： A61K31/535 , A61K31/485 , A61K31/5377 , C07D413/12
摘要： The invention relates to pyrazole derivatives of formula I having pharmacological activity and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of pain.
摘要翻译： 本发明涉及具有药理活性的式I的吡唑衍生物及其制备方法，包括它们的药物组合物，以及它们在治疗和/或预防疼痛中的用途。
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2.发明授权公开(公告)号：US06353117B1
公开(公告)日：2002-03-05
申请号：US09701276
申请日：2000-11-28
申请人： María Rosa Cuberes-Altisent , Juana María Berrocal-Romero , María Montserrat Contijoch-Llobet , Jordi Frigola-Constansa
发明人： María Rosa Cuberes-Altisent , Juana María Berrocal-Romero , María Montserrat Contijoch-Llobet , Jordi Frigola-Constansa
IPC分类号： C07D23106
CPC分类号： C07D231/06
摘要： The present invention relates to new pyazoline derivatives of formula and to physiologically acceptable salts thereof, to the method for their preparation and to their application as medicaments.
摘要翻译： 本发明涉及式的新的吡唑啉衍生物及其生理上可接受的盐，其制备方法及其作为药物的应用。
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公开(公告)号：US07696199B2
公开(公告)日：2010-04-13
申请号：US11574361
申请日：2005-08-29
申请人： Christian Laggner , María Rosa Cuberes-Altisent , Joerg Holenz , Juana María Berrocal-Romero , María Montserrat Contijoch-Llobet
发明人： Christian Laggner , María Rosa Cuberes-Altisent , Joerg Holenz , Juana María Berrocal-Romero , María Montserrat Contijoch-Llobet
IPC分类号： A61K31/4152 , A61K31/4155 , A61K31/5377 , C07D413/02 , C07D413/12 , C07D231/22
CPC分类号： C07D471/04 , C07D231/22 , C07D401/12 , C07D403/12
摘要： The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
摘要翻译： 本发明涉及具有对σ受体的药理学活性的式（I）化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/或预防其中σ受体 参与。
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公开(公告)号：US08470867B2
公开(公告)日：2013-06-25
申请号：US12703112
申请日：2010-02-09
申请人： Christian Laggner , María Rosa Cuberes-Altisent , Joerg Holenz , Juana María Berrocal-Romero , Maria Montserrat Contijoch-Llobet
发明人： Christian Laggner , María Rosa Cuberes-Altisent , Joerg Holenz , Juana María Berrocal-Romero , Maria Montserrat Contijoch-Llobet
IPC分类号： C07D231/22
CPC分类号： C07D471/04 , C07D231/22 , C07D401/12 , C07D403/12
摘要： The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
摘要翻译： 本发明涉及具有对σ受体的药理学活性的式（I）化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/或预防其中σ受体 参与。
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