公开(公告)号：US07888498B2

公开(公告)日：2011-02-15

申请号：US11751283

申请日：2007-05-21

申请人： Antonin De Fougerolles ,  Andrew Sprague ,  Jens Harborth ,  Maria Gabriela Belvisi ,  Mark Andrew Birrell ,  Elizabeth Louise Hardaker ,  Matthew Copeland Catley

发明人： Antonin De Fougerolles ,  Andrew Sprague ,  Jens Harborth ,  Maria Gabriela Belvisi ,  Mark Andrew Birrell ,  Elizabeth Louise Hardaker ,  Matthew Copeland Catley

IPC分类号： C07H21/04 ,  C12N15/11

CPC分类号： C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3515 ,  C12Y207/1101 ,  C12N2310/3521

摘要： The invention relates to a doable-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the IKK-B gene, comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the IKK-B gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases, caused by the expression or activation of the IKK-B gene using the pharmaceutical composition; and methods for inhibiting the expression of the IKK-B gene in a cell.

摘要翻译： 本发明涉及用于抑制IKK-B基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸，长度通常为19-25个核苷酸的核苷酸序列的反义链，以及 其基本上与IKK-B基因的至少一部分互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于使用该药物组合物治疗由IKK-B基因的表达或活化引起的疾病的方法; 以及抑制细胞中IKK-B基因表达的方法。

公开(公告)号：US09000143B2

公开(公告)日：2015-04-07

申请号：US12982261

申请日：2010-12-30

申请人： Antonin de Fougerolles ,  Andrew Sprague ,  Jens Harborth ,  Maria Gabriela Belvisi ,  Mark Andrew Birrell ,  Elizabeth Louise Hardaker ,  Matthew Copeland Catley

发明人： Antonin de Fougerolles ,  Andrew Sprague ,  Jens Harborth ,  Maria Gabriela Belvisi ,  Mark Andrew Birrell ,  Elizabeth Louise Hardaker ,  Matthew Copeland Catley

IPC分类号： C07H21/04 ,  C12N15/113

CPC分类号： C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3515 ,  C12Y207/1101 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the IKK-B gene, comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the IKK-B gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression or activation of the IKK-B gene using the pharmaceutical composition; and methods for inhibiting the expression of the IKK-B gene in a cell.

摘要翻译： 本发明涉及用于抑制IKK-B基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸，长度通常为19-25个核苷酸的核苷酸序列的反义链，以及 其基本上与IKK-B基因的至少一部分互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 使用该药物组合物治疗由IKK-B基因的表达或活化引起的疾病的方法; 以及抑制细胞中IKK-B基因表达的方法。