公开(公告)号：US20080188509A1

公开(公告)日：2008-08-07

申请号：US12059106

申请日：2008-03-31

申请人： Arata TOSHIMITSU ,  Kazunosuke AIDA ,  Takaaki TERAHARA ,  Naruhito HIGO

发明人： Arata TOSHIMITSU ,  Kazunosuke AIDA ,  Takaaki TERAHARA ,  Naruhito HIGO

IPC分类号： A61K31/48

CPC分类号： A61K9/7061 ,  A61K9/7076 ,  A61K31/48

摘要： It is intended to provide pergolide-containing transdermal preparations having reduced side effects and exerting sufficient therapeutic effects. Namely, a pergolide-containing transdermal preparation which is capable of achieving a plasma AUC ratio of pergolide or the like to at least one pergolide metabolite of 1:0.5 to 1:5; and/or transdermal preparation containing pergolide and/or a pharmaceutically acceptable salt thereof which is capable of achieving a ratio (A/B) of the maximum plasma level (A) of pergolide and/or a pharmaceutically acceptable salt thereof to the plasma level (B) thereof in the next administration of less than 2.

摘要翻译： 本发明旨在提供具有降低的副作用并发挥足够治疗效果的含pergolide的透皮制剂。 即，含有速溶胶的透皮制剂，能够实现速溶胶等的血浆AUC比例为1:0.5至1:5的至少一种pergolide代谢物; 和/或透皮制剂，其含有速溶胶和/或其药学上可接受的盐，其能够实现血浆白蛋白的最大血浆水平（A）和/或其药学上可接受的盐与血浆水平的比（A / B） B）在下一次给药时不到2次。

公开(公告)号：US20090208560A1

公开(公告)日：2009-08-20

申请号：US12385935

申请日：2009-04-24

申请人： Kazunosuke AIDA ,  Arata TOSHIMITSU ,  Takaaki TERAHARA ,  Naruhito HIGO

发明人： Kazunosuke AIDA ,  Arata TOSHIMITSU ,  Takaaki TERAHARA ,  Naruhito HIGO

IPC分类号： A61K9/00 ,  A61P17/00

CPC分类号： A61K9/7084 ,  A61F2013/00646 ,  A61L15/44 ,  A61L2300/40 ,  A61L2300/608

摘要： A cover material adapted to cover the entirety of a patch is provided. The cover material has a support layer and, superimposed on a surface thereof, a pressure sensitive adhesive layer. The patch has a support film with a thickness of 12- to 30 μm and, superimposed thereon, a drug containing layer. The cover material may be attached to the surface of the support film and to the skin around the patch so that the pressure sensitive adhesive layer is brought into contact with edges of the drug containing layer. Additionally, the pressure sensitive adhesive layer contains an adhesive resulting from the polymerization of vinyl acetate or N-vinyl-2-pyrrolidone and a C8 alkyl (meth)acrylate as essential monomers. Thus, there is provided a cover material that, when a patch medicated with, for example, mesylic acid pergolide is fixed on diseased part, such as, a part of the skin, by covering the patch, is capable of reducing irritation, etc. on the diseased part.

摘要翻译： 提供适于覆盖整个贴片的覆盖材料。 覆盖材料具有支撑层，并且在其表面上叠加压敏粘合剂层。 该贴片具有厚度为12至30μm的支撑膜，并且叠加在其上的含药层。 覆盖材料可以附着到支撑膜的表面和贴片周围的皮肤，使得压敏粘合剂层与含药层的边缘接触。 此外，压敏粘合剂层包含由乙酸乙烯酯或N-乙烯基-2-吡咯烷酮和（甲基）丙烯酸C8烷基酯作为必需单体的聚合得到的粘合剂。 因此，提供了一种覆盖材料，其在例如通过覆盖片剂的情况下固定在患病部位（例如皮肤的一部分）上的情况下，能够减少刺激等。 在患病部位。