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公开(公告)号:US20210317468A1
公开(公告)日:2021-10-14
申请号:US17239369
申请日:2021-04-23
Applicant: Arcturus Therapeutics, Inc.
Inventor: Pattraranee Limphong , Carlos G. Perez-Garcia , Kiyoshi Tachikawa , Padmanabh Chivukula , Arisa Cale , Angel I-Jou Leu , Jared Davis
IPC: C12N15/82 , C12N15/52 , C07K14/805 , C07K14/775 , C07K14/75 , C07K14/47 , C07K14/415 , C07K14/505
Abstract: This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.
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公开(公告)号:US20190002906A1
公开(公告)日:2019-01-03
申请号:US15994683
申请日:2018-05-31
Applicant: Arcturus Therapeutics, Inc.
Inventor: Pattraranee Limphong , Carlos G. Perez-Garcia , Kiyoshi Tachikawa , Padmanabh Chivukula , Arisa Cale , Angel I-Jou Leu , Jared Davis
IPC: C12N15/82 , C12N15/52 , C07K14/805 , C07K14/775 , C07K14/75 , C07K14/47 , C07K14/415
Abstract: This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.
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公开(公告)号:US11015204B2
公开(公告)日:2021-05-25
申请号:US15994683
申请日:2018-05-31
Applicant: Arcturus Therapeutics, Inc.
Inventor: Pattraranee Limphong , Carlos G. Perez-Garcia , Kiyoshi Tachikawa , Padmanabh Chivukula , Arisa Cale , Angel I-Jou Leu , Jared Davis
IPC: C12N15/52 , C12N15/82 , C07K14/805 , C07K14/775 , C07K14/75 , C07K14/47 , C07K14/415 , C07K14/505 , A61K38/01 , A61K38/17 , A61K38/42 , A61K38/36 , A61K38/18
Abstract: This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.
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