公开(公告)号：US20160215293A1

公开(公告)日：2016-07-28

申请号：US15097001

申请日：2016-04-12

Applicant: Arcturus Therapeutics, Inc.

Inventor： Michael V. Templin ,  Narendra K. Vaish ,  Barry A. Polisky ,  Michael E. Houston, JR.

IPC: C12N15/113

CPC classification number: C12N15/1138 ,  C12N15/113 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2310/32 ,  C12N2310/323 ,  C12N2320/30

Abstract: This invention provides oligomer structures for therapeutic agents, the oligomers composed of one or more UNA nucleomonomers, along with nucleic acid monomers. The UNA oligomers may be used as therapeutic agents for treating or preventing disease. The UNA oligomers can be capable of modulating or silencing gene expression, through RNA interference or other modalities, and may have an antisense strand and a sense strand.

Abstract translation: 本发明提供用于治疗剂的低聚物结构，由一种或多种UNA核单体组成的低聚物以及核酸单体。 UNA寡聚体可以用作治疗或预防疾病的治疗剂。 UNA寡聚体可以通过RNA干扰或其他方式调节或沉默基因表达，并且可以具有反义链和有义链。