公开(公告)号：US20220241263A1

公开(公告)日：2022-08-04

申请号：US17615735

申请日：2020-05-29

Applicant: Ares Trading S.A. ,  Pfizer Inc.

Inventor： Marat Alimzhanov ,  Keith Anthony Ching ,  Alessandra Di Pietro ,  Xinmeng Mu ,  Paul Brian Robbins

IPC: A61K31/4439 ,  A61K39/395 ,  C07K16/28 ,  A61P35/00

Abstract: The present disclosure describes combination therapies comprising a PD-1 axis binding antagonist, wherein the cancer has been pre-determined to have one or more genetic mutations in one or more genes, to have certain gene expression profiles, and/or to have other biomarkers.