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公开(公告)号:US20230099837A1
公开(公告)日:2023-03-30
申请号:US17792917
申请日:2021-01-22
IPC分类号: A61K31/437 , A61K31/4402 , A61P25/28
摘要: This invention relates generally to neurodegenerative diseases and conditions (e.g., Alzheimer's disease) characterized with aberrant RIPK1/RIPK3 binding, RIPK3/MLKL binding, necrosome formation, and/or necroptosis activation. This invention further relates to methods and compositions for treating such neurodegenerative diseases and conditions with pharmaceutical compositions comprising agents capable of inhibiting RIPK1/RIPK3 binding and/or RIPK3/MLKL binding.