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    Label-free single molecule spectroscopy and detection
    2.
    发明授权
    Label-free single molecule spectroscopy and detection 有权

    公开(公告)号：US11378516B2

    公开(公告)日：2022-07-05

    申请号：US16765810

    申请日：2019-02-07

    申请人： Arizona Board of Regents on Behalf of the University of Arizona

    发明人： Tsu-Te Judith Su

    IPC分类号： G01N21/64 ,  G02B17/00

    摘要： A label-free detection and characterization system includes an optical source; an optical path arranged to be optically coupled to the optical source; an optical resonator disposed proximate the optical path along a side of the optical path, the optical resonator having an optical whispering-gallery mode and being optically coupled to the optical path through an evanescent field to excite the optical whispering-gallery mode; an optical receiver arranged to be optically coupled to the optical path. The optical source is frequency locked to a resonance frequency of the optical resonator and provides light sufficiently intense to provide four-wave mixing while being coupled with the optical resonator resulting in a comb spectrum received by the optical receiver. The comb spectrum provides characteristic changes in the presence of a substance in contact with the optical resonator to provide detection and characterization of the substance.