公开(公告)号：US20220221447A1

公开(公告)日：2022-07-14

申请号：US17614998

申请日：2020-05-29

申请人： Arizona Board of Regents on Behalf of the University of Arizona, a body corporate

发明人： Craig Aspinwall ,  Colleen Janczak

IPC分类号： G01N33/533 ,  G01N33/542 ,  C09K11/02 ,  C09K11/06 ,  C08K5/01 ,  C08K5/3415

摘要： The present invention provides a process for producing a nanocomposite particle (“nanoSCINT particle”) adapted for use in scintillating proximity assay in a relatively high quantity. The nanoSCINT particle comprises a silica shell that encapsulates a nanoparticle organic polymer that is doped with at least one scintillating compound. In particular, the process of the invention includes adding a plurality of batch-wise portions of a polymerization initiator to an emulsion comprising a relatively high amount of polymerizable organic compound to produce a nanoparticle organic polymer, which is then doped with at least one scintillating compound, and then encapsulated with a silica shell to produce nanoSCINT particles in gram quantities in a single process. Unlike conventional methods, a single process of the invention provides at least about 5 g, typically at least about 7.5 g, and often at least about 10 g of nanocomposite particles.