公开(公告)号：US20210223257A1

公开(公告)日：2021-07-22

申请号：US17249863

申请日：2021-03-16

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Stephen Albert JOHNSTON ,  Phillip STAFFORD ,  Jian ZHANG ,  Luhui SHEN

IPC: G01N33/68 ,  A61K39/00 ,  A61K45/06

Abstract: Disclosed herein are methods and systems for determining microsatellite instability. In some embodiments, the disclosed methods and systems are used for determining whether a cancer patient has high microsatellite instability (MSI-H). MSI-H patients have remarkably good responses to immunotherapy, such as checkpoint inhibitors immunotherapy. Therefore, the disclosed methods and systems can be used for identifying MSI-H and thus, patients as candidates for immunotherapy. In turn, the disclosed methods and systems can be used to predict responsiveness to immunotherapy. In some embodiments, the methods further include providing an immunotherapy to the MSI-H patient. Also disclosed are vaccines and compositions.