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公开(公告)号：US20160097759A1
公开(公告)日：2016-04-07
申请号：US14851933
申请日：2015-09-11
Inventor： Stuart LINDSAY , Shuai CHANG , Jin HE , Peiming ZHANG , Shuo HUANG
IPC: G01N33/487 , G01N27/327 , C12Q1/68
CPC classification number: G01N33/48721 , C12Q1/6869 , G01N27/3275 , Y10T436/143333
Abstract: The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.
Abstract translation: 本发明包括用于分析聚合物和/或聚合物单元的组合物，装置和方法。 聚合物可以是同质或异聚合物，例如DNA，RNA，多糖或肽。 该装置包括形成隧道间隙的电极，聚合物可通过该间隙通过。 电极用附着于其上的试剂进行功能化，并且试剂能够形成与聚合物单元的暂时结合。 当试剂和单元之间形成瞬态键时，产生可检测的信号并用于分析聚合物。
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公开(公告)号：US20180224422A1
公开(公告)日：2018-08-09
申请号：US15712552
申请日：2017-09-22
Inventor： Stuart LINDSAY , Shuai CHANG , Jin HE , Peiming ZHANG , Shuo HUANG
IPC: G01N33/487 , G01N27/327 , C12Q1/6869
CPC classification number: G01N33/48721 , C12Q1/6869 , G01N27/3275 , Y10T436/143333
Abstract: The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.
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