公开(公告)号：US20230113468A1

公开(公告)日：2023-04-13

申请号：US18072459

申请日：2022-11-30

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Nongjian Tao ,  Wenwen Jing

IPC: B01L3/00 ,  G01N1/38 ,  G01N33/543

Abstract: A method for detecting biomarkers with shortened test time and enhanced precision is provided. A sample from the body fluid is made to flow over a sensor surface coated with a capture antibody to allow binding of a biomarker in the sample to the capture body. An optical method detects and counts the individual binding events along the sensor surface with single molecule resolution, and difference in the binding events along the sensor surface is detected in real-time and analyzed to determine the biomarker concentration.

公开(公告)号：US11559807B2

公开(公告)日：2023-01-24

申请号：US16689530

申请日：2019-11-20

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Nongjian Tao ,  Wenwen Jing

IPC: G01N33/543 ,  B01L3/00 ,  G01N1/38

Abstract: A method for detecting biomarkers with shortened test time and maximized precision. A sample from the body fluid is made to flow over a sensor surface coated with a capture antibody to allow binding of a biomarker in the sample to the capture body. An optical method detects and counts the individual binding events along the sensor surface with single molecule resolution, and difference in the binding events along the sensor surface is detected in real time and analyzed to determine the biomarker concentration.