公开(公告)号：US20140275013A1

公开(公告)日：2014-09-18

申请号：US14209536

申请日：2014-03-13

申请人： Arnab Kumar CHATTERJEE ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Pranab Kumar MISHRA ,  Valentina MOLTENI ,  Advait Suresh Nagle ,  Frantisek SUPEK ,  Liying Jocelyn TAN ,  Agnes VIDAL ,  Michael Herman GELB ,  Frederick Simmons BUCKNER ,  Hari Babu TATIPAKA ,  Neil Richard NORCROSS ,  John Robert GILLESPIE

发明人： Arnab Kumar CHATTERJEE ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Pranab Kumar MISHRA ,  Valentina MOLTENI ,  Advait Suresh Nagle ,  Frantisek SUPEK ,  Liying Jocelyn TAN ,  Agnes VIDAL ,  Michael Herman GELB ,  Frederick Simmons BUCKNER ,  Hari Babu TATIPAKA ,  Neil Richard NORCROSS ,  John Robert GILLESPIE

IPC分类号： C07D473/00 ,  C07D471/04

CPC分类号： C07D473/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

公开(公告)号：US20140274926A1

公开(公告)日：2014-09-18

申请号：US14209655

申请日：2014-03-13

申请人： Arnab Kumar CHATTERJEE ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Pranab Kumar MISHRA ,  Valentina MOLTENI ,  Advait Suresh NAGLE ,  Frantisek SUPEK ,  Liying Jocelyn TAN ,  Agnes VIDAL

发明人： Arnab Kumar CHATTERJEE ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Pranab Kumar MISHRA ,  Valentina MOLTENI ,  Advait Suresh NAGLE ,  Frantisek SUPEK ,  Liying Jocelyn TAN ,  Agnes VIDAL

IPC分类号： A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  A61K31/437 ,  C07D498/04

CPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K45/06 ,  C07D471/04 ,  C07D498/04 ,  Y02A50/409 ,  Y02A50/414 ,  Y02A50/415

摘要： The present invention provides compounds of Formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯 疾病。

公开(公告)号：US20140275119A1

公开(公告)日：2014-09-18

申请号：US14209850

申请日：2014-03-13

申请人： Fang LIANG ,  Pranab Kumar MISHRA ,  Valentina MOLTENI ,  Advait Suresh NAGLE ,  Frantisek SUPEK ,  Liying Jocelyn TAN ,  Agnes VIDAL

发明人： Fang LIANG ,  Pranab Kumar MISHRA ,  Valentina MOLTENI ,  Advait Suresh NAGLE ,  Frantisek SUPEK ,  Liying Jocelyn TAN ,  Agnes VIDAL

IPC分类号： C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  Y02A50/409 ,  Y02A50/414 ,  Y02A50/415 ,  A61K2300/00

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯 疾病。

公开(公告)号：US20150175613A1

公开(公告)日：2015-06-25

申请号：US14574775

申请日：2014-12-18

申请人： Agnes BIGGART ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Valentina MOLTENI ,  Advait Suresh NAGLE ,  Frantisek SUPEK ,  Vince YEH

发明人： Agnes BIGGART ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Valentina MOLTENI ,  Advait Suresh NAGLE ,  Frantisek SUPEK ,  Vince YEH

IPC分类号： C07D487/04 ,  C07F5/02 ,  C07D519/00 ,  C07F7/08

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F5/027 ,  C07F7/0814

摘要： The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

摘要翻译： 本发明提供式A化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供了包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯 疾病。

公开(公告)号：US20160303129A1

公开(公告)日：2016-10-20

申请号：US15051446

申请日：2016-02-23

申请人： Agnes BIGGART ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Valentina MOLTENI ,  Advait Suresh Nagle ,  Frantisek SUPEK ,  Vince YEH

发明人： Agnes BIGGART ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Valentina MOLTENI ,  Advait Suresh Nagle ,  Frantisek SUPEK ,  Vince YEH

IPC分类号： A61K31/519 ,  A61K31/695 ,  A61K31/5377

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F5/027 ,  C07F7/0814

摘要： The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

摘要翻译： 或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供了包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯 疾病。

公开(公告)号：US20160045505A1

公开(公告)日：2016-02-18

申请号：US14776663

申请日：2014-03-13

申请人： Agnes VIDAL ,  Pranab Kumar MISHRA

发明人： Jan JIRICEK ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Pranab Kumar MISHRA ,  Valentina MOLTENI ,  Advait Suresh Nagle ,  Frantisek SUPEK ,  Liying Jocelyn TAN ,  Agnes VIDAL ,  Vince YEH

IPC分类号： A61K31/519 ,  C07D519/00 ,  A61K31/695 ,  A61K31/553 ,  C07F7/08 ,  C07D487/04 ,  A61K31/5377

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/553 ,  A61K31/695 ,  C07D487/04 ,  C07D491/08 ,  C07D491/107 ,  C07D519/00 ,  C07F7/0814 ,  Y02A50/409 ,  Y02A50/414 ,  Y02A50/415

摘要： The present invention provides compounds of formula (I): (Formula (I)) or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

摘要翻译： 本发明提供式（I）化合物：（式（I））或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯 疾病。

公开(公告)号：US20120302570A1

公开(公告)日：2012-11-29

申请号：US13567386

申请日：2012-08-06

申请人： Miao DAI ,  Xingnian FU ,  Feng HE ,  Lei JIANG ,  Yue LI ,  Fang LIANG ,  Lei LIU ,  Yuan MI ,  Yao-Chang XU ,  Guoliang XUN ,  Xiaoxia YAN ,  Zhengtian YU ,  Ji Yue ZHANG

发明人： Miao DAI ,  Xingnian FU ,  Feng HE ,  Lei JIANG ,  Yue LI ,  Fang LIANG ,  Lei LIU ,  Yuan MI ,  Yao-Chang XU ,  Guoliang XUN ,  Xiaoxia YAN ,  Zhengtian YU ,  Ji Yue ZHANG

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61K31/519 ,  A61K31/4985 ,  A61K31/53

CPC分类号： C07D471/04

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

摘要翻译： 本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

公开(公告)号：US20110065708A1

公开(公告)日：2011-03-17

申请号：US12859653

申请日：2010-08-19

申请人： Miao DAI ,  Xingnian FU ,  Feng HE ,  Lei JIANG ,  Yue LI ,  Fang LIANG ,  Lei LIU ,  Yuan MI ,  Yao-chang XU ,  Guoliang XUN ,  Xiaoxia YAN ,  Zhengtian YU ,  Ji Yue ZHANG

发明人： Miao DAI ,  Xingnian FU ,  Feng HE ,  Lei JIANG ,  Yue LI ,  Fang LIANG ,  Lei LIU ,  Yuan MI ,  Yao-chang XU ,  Guoliang XUN ,  Xiaoxia YAN ,  Zhengtian YU ,  Ji Yue ZHANG

IPC分类号： A61K31/53 ,  C07D487/04 ,  A61K31/5025 ,  A61K31/498 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

摘要翻译： 本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

公开(公告)号：US20130245002A1

公开(公告)日：2013-09-19

申请号：US13613291

申请日：2012-09-13

申请人： Chao CHEN ,  Haibing DENG ,  Haibing GUO ,  Feng HE ,  Lei JIANG ,  Fang LIANG ,  Yuan MI ,  Huixin WAN ,  Yao-Chang XU ,  Hongping YU ,  Ji Yue ZHANG

发明人： Chao CHEN ,  Haibing DENG ,  Haibing GUO ,  Feng HE ,  Lei JIANG ,  Fang LIANG ,  Yuan MI ,  Huixin WAN ,  Yao-Chang XU ,  Hongping YU ,  Ji Yue ZHANG

IPC分类号： C07D471/04 ,  A61K31/496 ,  A61K31/5513 ,  A61K31/5377 ,  C07D491/107 ,  A61K45/06 ,  A61K31/437

CPC分类号： A61K31/551 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5513 ,  A61K45/06 ,  C07D471/04 ,  C07D491/107 ,  C07D519/00

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).