公开(公告)号：US20170172988A1

公开(公告)日：2017-06-22

申请号：US15392963

申请日：2016-12-28

Applicant: Array BioPharma Inc.

Inventor： Brian J. Tunquist ,  Duncan H. Walker ,  Richard D. Woessner

IPC: A61K31/433

CPC classification number: A61K31/433 ,  A61K31/00

Abstract: Methods of treating diseases caused by cell division or that are treated by inhibiting mitosis by administering two doses of an inhibitor of mitosis between the biologically effective dose and the maximum tolerated dose in a dosing cycle that allows for the recovery or subsiding of side effects, wherein the second dose is administered 24 to 48 hours after the first dose.

公开(公告)号：US20180338958A1

公开(公告)日：2018-11-29

申请号：US16000756

申请日：2018-06-05

Applicant: Array BioPharma Inc.

Inventor： Brian J. Tunquist ,  Duncan HL. Walker ,  Richard D. Woessner

IPC: A61K31/433 ,  A61K31/00

Abstract: Methods of treating diseases caused by cell division or that are treated by inhibiting mitosis by administering two doses of an inhibitor of mitosis between the biologically effective dose and the maximum tolerated dose in a dosing cycle that allows for the recovery or subsiding of side effects, wherein the second dose is administered 24 to 48 hours after the first dose.