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    ITK and JAK Kinase Inhibitors
    1.
    发明申请
    ITK and JAK Kinase Inhibitors 审中-公开
    ITK和JAK激酶抑制剂

    公开(公告)号：US20160046627A1

    公开(公告)日：2016-02-18

    申请号：US14924427

    申请日：2015-10-27

    申请人： Arrien Pharmaceuticals LLC

    发明人： Hariprasad Vankayalapati ,  Venkatakrishnareddy Yerramreddy ,  Paramareddy Gangireddy ,  Rajendra P. Appalaneni

    IPC分类号： C07D471/04 ,  C07D487/04

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The present invention relates to compounds described by Formula I: salts thereof, their synthesis, and their use as ITK and JAK3 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such disease associated with abnormal cell growth such as autoimmune, inflammation, rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis, ulcerative colitis, psoriatic arthritis, psoriasis, Crohn's, metabolic and cancer diseases. The present invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions and processes for preparing the compounds of the invention.

    摘要翻译： 本发明涉及式I所述的化合物：其盐，它们的合成及其作为包括这些化合物的ITK和JAK3抑制剂的用途以及使用所述化合物治疗各种疾病和/或障碍的方法，所述疾病与异常细胞生长相关 例如自身免疫，炎症，类风湿性关节炎，系统性红斑狼疮，动脉粥样硬化，溃疡性结肠炎，银屑病关节炎，牛皮癣，克罗恩病，代谢和癌症疾病。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用组合物和制备本发明化合物的方法的方法。

    3,5-(Un)substituted-1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H- pyrrolo[2,3-b]pyrazine dual ITK and JAK3 Kinase Inhibitors
    2.
    发明申请
    3,5-(Un)substituted-1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H- pyrrolo[2,3-b]pyrazine dual ITK and JAK3 Kinase Inhibitors 有权
    3,5-（Un）取代-1H-吡咯并[2,3-b]吡啶，1H-吡唑并[3,4-b]吡啶和5H-吡咯并[2,3-b]吡嗪双ITK和JAK3激酶抑制剂

    公开(公告)号：US20140315909A1

    公开(公告)日：2014-10-23

    申请号：US14254398

    申请日：2014-04-16

    申请人： Arrien Pharmaceuticals LLC

    发明人： Hariprasad Vankayalapati ,  Venkatakrishnareddy Yerramreddy ,  Paramareddy Gangireddy ,  Rajendra P. Appalaneni

    IPC分类号： C07D487/04 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The present invention relates to compounds described by Formula I: salts thereof, their synthesis, and their use as ITK and JAK3 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such disease associated with abnormal cell growth such as autoimmune, inflammation, rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis, ulcerative colitis, psoriatic arthritis, psoriasis, Crohn's, metabolic and cancer diseases. The present invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions and processes for preparing the compounds of the invention.

    摘要翻译： 本发明涉及式I所述的化合物：其盐，它们的合成及其作为包括这些化合物的ITK和JAK3抑制剂的用途以及使用所述化合物治疗各种疾病和/或障碍的方法，所述疾病与异常细胞生长相关 例如自身免疫，炎症，类风湿性关节炎，系统性红斑狼疮，动脉粥样硬化，溃疡性结肠炎，银屑病关节炎，牛皮癣，克罗恩病，代谢和癌症疾病。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用组合物和制备本发明化合物的方法的方法。

    Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
    4.
    发明授权
    Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors 有权
    取代的吡咯并[2,3-b]吡啶，为ITK和JAK抑制剂

    公开(公告)号：US09206188B2

    公开(公告)日：2015-12-08

    申请号：US14254398

    申请日：2014-04-16

    申请人： Arrien Pharmaceuticals LLC

    发明人： Hariprasad Vankayalapati ,  Venkatakrishnareddy Yerramreddy ,  Paramareddy Gangireddy ,  Rajendra P. Appalaneni

    IPC分类号： C07D471/04 ,  C07D487/04

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The present invention relates to compounds described by Formula I: salts thereof, their synthesis, and their use as ITK and JAK3 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such disease associated with abnormal cell growth such as autoimmune, inflammation, rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis, ulcerative colitis, psoriatic arthritis, psoriasis, Crohn's, metabolic and cancer diseases. The present invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions and processes for preparing the compounds of the invention.

    摘要翻译： 本发明涉及式I所述的化合物：其盐，它们的合成及其作为包括这些化合物的ITK和JAK3抑制剂的用途以及使用所述化合物治疗各种疾病和/或障碍的方法，所述疾病与异常细胞生长相关 例如自身免疫，炎症，类风湿性关节炎，系统性红斑狼疮，动脉粥样硬化，溃疡性结肠炎，银屑病关节炎，牛皮癣，克罗恩病，代谢和癌症疾病。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用组合物和制备本发明化合物的方法的方法。