公开(公告)号：US20240335444A1

公开(公告)日：2024-10-10

申请号：US18407150

申请日：2024-01-08

Applicant: Arvinas Operations, Inc.

Inventor： Dan SHERMAN ,  Sheryl Maxine GOUGH

IPC: A61K31/506 ,  A61P35/00

CPC classification number: A61K31/506 ,  A61P35/00

Abstract: This application pertains to the use of compounds, e.g., Compound A:




or a pharmaceutically acceptable salt thereof, for the treatment of various diseases or disorders, including, for example, diffuse large B-cell lymphoma (DLBCL) and angioimmunoblastic T-cell lymphoma.

公开(公告)号：US20240190841A1

公开(公告)日：2024-06-13

申请号：US18490704

申请日：2023-10-19

Applicant: Arvinas Operations, Inc.

Inventor： Dan SHERMAN

IPC: C07D401/14 ,  A61K31/506 ,  A61K45/06 ,  C07D471/04

CPC classification number: C07D401/14 ,  A61K31/506 ,  A61K45/06 ,  C07D471/04

Abstract: This disclosure pertains to bifunctional compounds, the preparation thereof, and the use of these bifunctional compounds in the treatment of diseases or disorders that result from aggregation or accumulation of B-cell lymphoma 6 protein, in subjects in need thereof.