公开(公告)号：US20250032587A1

公开(公告)日：2025-01-30

申请号：US18891744

申请日：2024-09-20

Applicant: ASCENDIS PHARMA ENDOCRINOLOGY DIVISION A/S

Inventor： Thomas Kurpiers ,  Harald Rau ,  Evelyn Exner ,  Steen Jensen ,  Grethe Nørskov Rasmussen ,  Torben Lessmann ,  Thomas Wegge ,  Alina Hermann ,  Nina Schubert ,  Anna Splanemann ,  Joachim Zettler

IPC: A61K38/27 ,  A61K9/08 ,  A61K47/12 ,  A61K47/20 ,  A61K47/26 ,  A61K47/60 ,  C08G65/334

Abstract: The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.

公开(公告)号：US10799563B2

公开(公告)日：2020-10-13

申请号：US15527744

申请日：2015-11-17

Applicant: Ascendis Pharma Endocrinology Division A/S

Inventor： Thomas Kurpiers ,  Harald Rau ,  Evelyn Exner ,  Steen Jensen ,  Grethe Nørskov Rasmussen ,  Torben Lessmann ,  Thomas Wegge ,  Alina Hermann ,  Nina Schubert ,  Anna Splanemann ,  Joachim Zettler

IPC: A61K38/27 ,  A61K47/60 ,  A61K9/08 ,  A61K47/12 ,  A61K47/20 ,  A61K47/26 ,  C08G65/334

Abstract: The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.

公开(公告)号：US12133883B2

公开(公告)日：2024-11-05

申请号：US17006589

申请日：2020-08-28

Applicant: Ascendis Pharma Endocrinology Division A/S

Inventor： Thomas Kurpiers ,  Harald Rau ,  Evelyn Exner ,  Steen Jensen ,  Grethe Nørskov Rasmussen ,  Torben Lessmann ,  Thomas Wegge ,  Alina Hermann ,  Nina Schubert ,  Anna Splanemann ,  Joachim Zettler

IPC: A61K38/27 ,  A61K9/08 ,  A61K47/12 ,  A61K47/20 ,  A61K47/26 ,  A61K47/60 ,  C08G65/334

Abstract: The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulation comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.

公开(公告)号：US20170354716A1

公开(公告)日：2017-12-14

申请号：US15527744

申请日：2015-11-17

Applicant: Ascendis Pharma Endocrinology Division A/S

Inventor： Thomas Kurpiers ,  Harald Rau ,  Evelyn Exner ,  Steen Jensen ,  Grethe Nørskov Rasmussen ,  Torben Lessmann ,  Thomas Wegge ,  Alina Hermann ,  Nina Schubert ,  Anna Splanemann ,  Joachim Zettler

IPC: A61K38/27 ,  A61K47/20 ,  A61K47/60 ,  A61K9/08 ,  C08G65/334 ,  A61K47/12 ,  A61K47/26

Abstract: The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.