公开(公告)号：US20070149486A1

公开(公告)日：2007-06-28

申请号：US11645757

申请日：2006-12-27

申请人： Ashok Kumar ,  Suneel Dike ,  Avinash Nijasure ,  Vijaya Bhaware

发明人： Ashok Kumar ,  Suneel Dike ,  Avinash Nijasure ,  Vijaya Bhaware

IPC分类号： A61K31/675 ,  C07F9/572

CPC分类号： C07F9/3873

摘要： The preset invention relates to a cost effective, high yielding, reproducible method for the manufacture of alendronic acid or its salt, such as sodium alendronate, from inexpensive and readily available pyrrolidone using phosphonating agents such as PCl3 in the presence of acids such as sulphonic acids, sulphuric acid or phosphoric acid, and pharmaceutical dosage forms of alendronic acid or pharmaceutically acceptable salts thereof.

摘要翻译： 本发明涉及一种成本有效，高产率，可重现的方法，用于使用膦酸化剂如PCl 3 N在廉价且易于获得的吡咯烷酮中制备阿仑膦酸或其盐，例如阿仑膦酸钠 存在酸例如磺酸，硫酸或磷酸，以及阿仑膦酸的药物剂型或其药学上可接受的盐。

公开(公告)号：US07414151B2

公开(公告)日：2008-08-19

申请号：US11645757

申请日：2006-12-27

申请人： Ashok Kumar ,  Suneel Yeshwant Dike ,  Avinash Manohar Nijasure ,  Vijaya Bhaware

发明人： Ashok Kumar ,  Suneel Yeshwant Dike ,  Avinash Manohar Nijasure ,  Vijaya Bhaware

IPC分类号： C07F9/38

CPC分类号： C07F9/3873

摘要： The preset invention relates to a cost effective, high yielding, reproducible method for the manufacture of alendronic acid or its salt, such as sodium alendronate, from inexpensive and readily available pyrrolidone using phosphonating agents such as PCl3 in the presence of acids such as sulphonic acids, sulphuric acid or phosphoric acid, and pharmaceutical dosage forms of alendronic acid or pharmaceutically acceptable salts thereof.

摘要翻译： 本发明涉及一种成本有效，高产率，可重现的方法，用于使用膦酸化剂如PCl 3 N在廉价且易于获得的吡咯烷酮中制备阿仑膦酸或其盐，例如阿仑膦酸钠 存在酸例如磺酸，硫酸或磷酸，以及阿仑膦酸的药物剂型或其药学上可接受的盐。