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公开(公告)号:US20100190773A1
公开(公告)日:2010-07-29
申请号:US12727570
申请日:2010-03-19
申请人: Asitha ABEYWARDANE , Craig Andrew MILLER , Tina Marie MORWICK , Neil MOSS , Matthew Russell NETHERTON , Roger John SNOW , Ji WANG , Jiang-Ping WU , Zhaoming XIONG
发明人: Asitha ABEYWARDANE , Craig Andrew MILLER , Tina Marie MORWICK , Neil MOSS , Matthew Russell NETHERTON , Roger John SNOW , Ji WANG , Jiang-Ping WU , Zhaoming XIONG
IPC分类号: A61K31/55 , C07D471/04 , A61K31/437 , C07D401/12 , A61K31/4439 , C07D487/04 , A61P3/10 , A61P1/00 , A61P19/02 , A61P25/28 , A61P9/04 , A61P11/06
CPC分类号: C07D471/02
摘要: Heterocyclic compounds and analogues thereof and their use as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.
摘要翻译: 杂环化合物及其类似物及其作为丝裂原活化蛋白激酶活化蛋白激酶-2(MAPKAP-k2)的抑制剂的用途,以及用于预防或治疗疾病或病症的方法,所述方法可以通过调节 MAPKAP-K2在受试者中的活性以及包括这些MAPKAP-K2抑制剂的药物组合物和试剂盒。