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公开(公告)号:US20230365559A1
公开(公告)日:2023-11-16
申请号:US18246100
申请日:2021-09-24
发明人: Benjamin D. DICKSON , Michael Patrick HAY , Cho Rong HONG , Way Wua WONG , William Robert WILSON , Lydia Pieng Ping LIEW , Stephen Michael Frazer JAMIESON
IPC分类号: C07D471/04 , C07D519/00 , A61P35/00
CPC分类号: C07D471/04 , C07D519/00 , A61P35/00
摘要: The invention relates to substituted imidazo[4,5-c]pyridine-2-one compounds of Formula (I) and prodrugs of said compounds. Compounds of Formula (I) selectively inhibit the activity of DNA-dependent protein kinase (DNA-PK) and are therefore useful in the treatment of diseases in which inhibition of DNA-PK is beneficial.