专利检索 ap:("Augusta University Research Institute, Inc.") AND inv:"Samir N. KHLEIF" 第 1 页

1.

发明申请
Compositions and Methods for Selectively Modulating Tregs 有权

公开(公告)号：US20210196817A1

公开(公告)日：2021-07-01

申请号：US17116627

申请日：2020-12-09

申请人： Augusta University Research Institute, Inc.

发明人： Samir N. KHLEIF , Mikayel MKRTICHYAN

IPC分类号： A61K39/39 , A61K31/427 , A61K31/52 , A61K31/5377 , A61K45/06

摘要： It has been discovered that PIK3δ (PIK3delta) selectively modulates the activation and proliferation of natural Tregs. Methods of modulating immune responses by modulating PIK3δ bioavailability or biological activity are provided.

2.

发明申请
Methods and Compositions for Inhibiting Akt3 审中-公开

公开(公告)号：US20200164067A1

公开(公告)日：2020-05-28

申请号：US16782811

申请日：2020-02-05

申请人： Augusta University Research Institute, Inc.

发明人： Samir N. KHLEIF , Mikayel MKRTICHYAN

IPC分类号： A61K39/39 , A61P35/00 , A61K39/00 , C07D401/14 , C07D401/12

摘要： Compounds and compositions for selectively inhibiting Akt3 are provided. Methods of using the compounds are also provided. Because Akt3 modulates the suppressive function of natural Tregs and the polarization of induced Tregs, the disclosed compounds are useful for modulating immune responses.