公开(公告)号：US20240100076A1

公开(公告)日：2024-03-28

申请号：US18262174

申请日：2022-01-19

申请人： Augusta University Research Institute, Inc.

发明人： Robert Yu ,  Yutaka Itokazu

IPC分类号： A61K31/7032 ,  A61P25/16 ,  A61P25/28

CPC分类号： A61K31/7032 ,  A61P25/16 ,  A61P25/28

摘要： Methods and compositions for treating neurodegenerative diseases are provided. In one embodiment, the method includes administering gangliosides into the brain of a mammal in need of such treatment. The gangliosiges are preferably GM1 and GD3 gangliosides. The gangliosides are intranasally administered in an amount effective to delay and/or prevent disease progression, and to increase the resilience of brains by promoting adult neurogenesis by gangliosides.