公开(公告)号：US20030187057A1

公开(公告)日：2003-10-02

申请号：US10290607

申请日：2002-11-08

申请人： Aventis Pharma Deutschland GmbH

发明人： Matthias Schiell ,  Martin Knauf ,  Luigi Toti ,  Astrid Markus-Erb

IPC分类号： A61K031/4015 ,  C07D207/273 ,  C12N001/20

CPC分类号： C07D207/44

摘要： The present invention relates to a compound of formula (I) 1 wherein the R, R2, R3, R4, R5, X, X2, X3, X4 and X5 are as defined herein, which are formed by the microorganism ST 003236 (DSM 14476) during fermentation, to a process for preparing and derivatizing the compound, to a pharmaceutical which comprises the compound and to a method for the treatment or prophylaxis of an infectious disease caused by bacteria comprising administering a pharmaceutically effective amount of the compound.

摘要翻译： 本发明涉及式（I）化合物，其中R，R2，R3，R4，R5，X，X2，X3，X4和X5如本文所定义，由微生物ST 003236（DSM14476）形成， 在发酵过程中，涉及制备和衍生化合物的方法，涉及包含该化合物的药物和用于治疗或预防由细菌引起的感染性疾病的方法，包括施用药学有效量的该化合物。

公开(公告)号：US20040122092A1

公开(公告)日：2004-06-24

申请号：US10676715

申请日：2003-10-01

申请人： Aventis Pharma Deutschland GmbH

发明人： Cordula Hopmann ,  Martin Knauf ,  Mark Bronstrup ,  Astrid Markus-Erb ,  Luigi Toti

IPC分类号： A61K031/255 ,  A61K031/235 ,  C07C069/76

CPC分类号： C07C69/88 ,  C07C305/24 ,  C12P7/6436 ,  C12R1/645

摘要： The present invention relates to novel hydroxyphenylundecane derivatives of the formula (I), 1 a method for the preparation of said compounds by cultivation of the fungus Cryphonectria parasitica, DSM 14453, and their use as pharmaceuticals, i.e. for the treatment of Alzheimer's Disease, Parkinson's Disease, Huntington's Diseases, stroke, psychosis and/or depressions.

摘要翻译： 本发明涉及式（I）的新型羟基苯基十一烷衍生物，通过培养真菌寄生真菌DSM 14453制备所述化合物的方法及其作为药物的用途，即用于治疗阿尔茨海默病，帕金森病 ，亨廷顿舞蹈病，中风，精神病和/或沮丧。