公开(公告)号：US20110097271A1

公开(公告)日：2011-04-28

申请号：US12867035

申请日：2009-02-11

申请人： Aviram Nissan ,  Stella Mitrani-Rosenbaum ,  Herbert Rudolf Freund ,  Tamar Peretz-Yablonsky ,  Marina Roistacher ,  Lloyd J. Old ,  Gerd Ritter ,  Ali O. Gure

发明人： Aviram Nissan ,  Stella Mitrani-Rosenbaum ,  Herbert Rudolf Freund ,  Tamar Peretz-Yablonsky ,  Marina Roistacher ,  Lloyd J. Old ,  Gerd Ritter ,  Ali O. Gure

IPC分类号： A61K49/00 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： The present invention relates to the identification, isolation, and sequencing of a unique nucleic acid transcript termed Colon Cancer Associated Transcript 1 (CCAT-1) that is specifically expressed in cancer cells, in particular in colon, rectal, and lung cancer, as well as in precancerous lesions. The present invention thus provides methods for diagnosing cancer by detecting the expression of CCAT-1 as well as isolated polynucleotides, compositions and kits for use in the detection methods of the invention.

摘要翻译： 本发明涉及在癌细胞特别是结肠癌，直肠癌和肺癌中特异性表达的称为结肠癌相关转录物1（CCAT-1）的独特核酸转录物的鉴定，分离和测序，以及 如癌前病变。 因此，本发明提供了通过检测CCAT-1的表达以及用于本发明的检测方法的分离的多核苷酸，组合物和试剂盒来诊断癌症的方法。