公开(公告)号：US20110060002A1

公开(公告)日：2011-03-10

申请号：US12448055

申请日：2007-12-03

申请人： Avraham Cohen ,  Francois Schutze ,  Suzy Charbit ,  Stéphane Bernad ,  Cuillaume Tauvel ,  Marie-Noëlle Petit ,  Gérard Coquerel

发明人： Avraham Cohen ,  Francois Schutze ,  Suzy Charbit ,  Stéphane Bernad ,  Cuillaume Tauvel ,  Marie-Noëlle Petit ,  Gérard Coquerel

IPC分类号： A61K31/444 ,  C07D471/04 ,  A61P1/04

CPC分类号： C07D471/04

摘要： The invention relates to conglomerates of tenatoprazole potassium salts of the following general formula (I), that consist of an equimolar mixture of enantiomers having R and S configurations and capable of crystallisation in the form of a conglomerate, wherein said salts are selected from tenatoprazole dehydrated potassium salt, tenatoprazole potassium dimethanolate, tenatoprazole potassium diethanolate and tenatoprazole potassium ethylene-glycolate. The invention also relates to a pharmaceutical composition containing such salt, and to the use of said salt.

摘要翻译： 本发明涉及由以下通式（I）组成的复合拉唑钾盐的组合物，其由具有R和S构型并能够以砾岩形式结晶的等摩尔混合物组成，其中所述盐选自硝酸唑 钾盐，替硝基拉唑钾二乙醇酸盐，十吖唑钾二乙醇酸盐和十吖唑醇乙醇 - 乙醇酸钾。 本发明还涉及含有该盐的药物组合物以及所述盐的用途。

公开(公告)号：US08546574B2

公开(公告)日：2013-10-01

申请号：US12448055

申请日：2007-12-03

申请人： Avraham Cohen ,  François Schutze ,  Suzy Charbit ,  Stéphane Bernad ,  Guillaume Tauvel ,  Marie-Noëlle Petit ,  Gérard Coquerel

发明人： Avraham Cohen ,  François Schutze ,  Suzy Charbit ,  Stéphane Bernad ,  Guillaume Tauvel ,  Marie-Noëlle Petit ,  Gérard Coquerel

IPC分类号： C07D471/04 ,  A61K31/444 ,  A61P1/04

CPC分类号： C07D471/04

摘要： The invention relates to conglomerates of tenatoprazole potassium salts of the following general formula (I), that consist of an equimolar mixture of enantiomers having R and S configurations and capable of crystallization in the form of a conglomerate, wherein said salts are selected from tenatoprazole dehydrated potassium salt, tenatoprazole potassium dimethanolate, tenatoprazole potassium diethanolate and tenatoprazole potassium ethylene-glycolate. The invention also relates to a pharmaceutical composition containing such salt, and to the use of said salt.

摘要翻译： 本发明涉及由以下通式（I）组成的具有R和S构型的能够以砾石形式结晶的对映异构体的等摩尔混合物的以下通式（I）的十位拉唑钾盐的组合物，其中所述盐选自硝酸唑 钾盐，替硝基拉唑钾二乙醇酸盐，十吖唑钾二乙醇酸盐和十吖唑醇乙醇 - 乙醇酸钾。 本发明还涉及含有该盐的药物组合物以及所述盐的用途。