公开(公告)号：US11866443B2

公开(公告)日：2024-01-09

申请号：US16614400

申请日：2018-05-09

Applicant: BASF Agro B.V.

Inventor： Klaus Ditrich ,  Michael Rack ,  Stefan Benson ,  Roland Goetz ,  Helmut Kraus

IPC: C07D493/08 ,  C07B57/00

CPC classification number: C07D493/08 ,  C07B57/00 ,  C07B2200/07

Abstract: The present invention relates to a method for separating an optically active hydroxy cineole derivatives by lixiviation and crystallization and enantiomerically pure optically active hydroxy cineole derivatives of purity greater than 99.5% that have been prepared by this process. The present invention further relates to use of the desired enantiomer having enantiomeric excess of at least 99.5% ee as prepared according to the present invention, for the synthesis of enantiomerically pure 7-oxabicyclo[2.2.1]heptane derivatives.

公开(公告)号：US20220033411A1

公开(公告)日：2022-02-03

申请号：US16614163

申请日：2018-05-09

Applicant: BASF Agro B.V.

Inventor： Klaus Ditrich ,  Michael Rack ,  Stefan Benson ,  Roland Goetz ,  Helmut Kraus

IPC: C07D493/08

Abstract: The present invention relates to a process for preparing optically active 1,4-cineole derivatives by enzymatic resolution and enantiomerically pure optically active 1,4-cineole derivatives of purity greater than 99.9% that have been prepared by this process. The present invention further relates to a process for preparing 7-oxabicyclo[2.2.1]heptane derivatives from the enantiomerically pure optically active 1,4-cineole derivatives.

公开(公告)号：US11639358B2

公开(公告)日：2023-05-02

申请号：US16614163

申请日：2018-05-09

Applicant: BASF Agro B.V.

Inventor： Klaus Ditrich ,  Michael Rack ,  Stefan Benson ,  Roland Goetz ,  Helmut Kraus

IPC: C07D493/08

Abstract: The present invention relates to a process for preparing optically active 1,4-cineole derivatives by enzymatic resolution and enantiomerically pure optically active 1,4-cineole derivatives of purity greater than 99.9% that have been prepared by this process. The present invention further relates to a process for preparing 7-oxabicyclo[2.2.1]heptane derivatives from the enantiomerically pure optically active 1,4-cineole derivatives.