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1.发明申请OVER-EXPRESSION OF A FATTY ACID TRANSPORTER GENE AND OF GENES ENCODING ENZYMES OF THE BETA-OXIDATION PATHWAY FOR HIGHER PRODUCTION OF RIBOFLAVIN VIA FERMENTATION OF EREMOTHECIUM 审中-公开过度表达脂肪酸运输基因和基因编码用于通过产生EREMOTHECIUM的更高产量的RIBOFLAVIN的氧化途径的酶公开(公告)号：US20160298160A1
公开(公告)日：2016-10-13
申请号：US15100376
申请日：2014-12-04
Applicant: BASF SE
Inventor： Birgit HOFF , Andrea MOLT , Stefan HAEFNER , Oskar ZELDER
Abstract: The present invention relates to a method of producing riboflavin in a genetically modified organism of the genus Eremothecium, wherein said genetic modification is linked to the fatty acid uptake and/or beta-oxidation pathway of said organism, comprising growing said organisms in a culture medium and isolating riboflavin from the culture medium. The invention further relates to a method of providing a riboflavin accumulating organism belonging to the genus Eremothecium by genetically modifying said organism, to organisms obtained by such a method, as well as the use of such genetically modified organisms for increasing the accumulation of riboflavin.
Abstract translation: 本发明涉及一种在Eremothecium的遗传修饰生物体中生产核黄素的方法，其中所述遗传修饰与所述生物体的脂肪酸摄取和/或β-氧化途径相关，包括在培养基中培养所述生物体 并从培养基中分离出核黄素。 本发明还涉及通过遗传修饰所述生物体，通过这种方法获得的生物体以及使用这种转基因生物来增加核黄素的积累来提供属于Eremothecium属的核黄素积聚生物体的方法。
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