公开(公告)号：US11657894B2

公开(公告)日：2023-05-23

申请号：US17772976

申请日：2021-07-06

Applicant: BASF SE

Inventor： Tong Li ,  Brian Standen ,  Dejan Caglic

IPC: G16B15/20 ,  G06N10/60 ,  G16B40/20 ,  G16B15/30

CPC classification number: G16B15/20 ,  G06N10/60 ,  G16B15/30 ,  G16B40/20

Abstract: Exemplary embodiments relate to a protein engineering pipeline configured to optimize or improve proteins for specified functions. The problem space of such a task can grow quickly based on the sequence of the protein being optimized and the functions for which the protein is being designed. The solutions described herein allow the problem space to be efficiently searched by applying a combination of a protein design pipeline and an evaluation procedure performed on a quantum computer. As a result, single or multiple amino acid substitutions at a site of interest may be predicted in order to generate optimized protein variants.

公开(公告)号：US20220089886A1

公开(公告)日：2022-03-24

申请号：US17251751

申请日：2019-06-24

Applicant: Yun HAN ,  BASF SE

Inventor： Yun Han ,  Adrienne Huston Davenport ,  Dejan Caglic ,  Michael Krayer ,  Tuan Tran

IPC: C09D7/65 ,  C09D7/61

Abstract: Disclosed herein are coating compositions comprising one or more enzymes that retain enzymatic activity following film formation. Uses of such functionalized coating compositions to confer bioactive properties to surfaces are also provided. Methods of enhancing in-film enzyme activity by modulation of filler type, pigment volume concentration (PVC), neutralizer type, and/or coalescing agent level are also provided.

公开(公告)号：US20230274789A1

公开(公告)日：2023-08-31

申请号：US18141199

申请日：2023-04-28

Applicant: BASF SE

Inventor： Tong Li ,  Brian Standen ,  Dejan Caglic

IPC: G16B15/20 ,  G16B40/20 ,  G16B15/30 ,  G06N10/60

CPC classification number: G16B15/20 ,  G16B40/20 ,  G16B15/30 ,  G06N10/60

Abstract: Exemplary embodiments relate to a protein engineering pipeline configured to optimize or improve proteins for specified functions. The problem space of such a task can grow quickly based on the sequence of the protein being optimized and the functions for which the protein is being designed. The solutions described herein allow the problem space to be efficiently searched by applying a combination of a protein design pipeline and an evaluation procedure performed on a quantum computer. As a result, single or multiple amino acid substitutions at a site of interest may be predicted in order to generate optimized protein variants.

公开(公告)号：US20230042150A1

公开(公告)日：2023-02-09

申请号：US17772976

申请日：2021-07-06

Applicant: BASF SE

Inventor： Tong Li ,  Brian Standen ,  Dejan Caglic

IPC: G16B15/20 ,  G16B15/30 ,  G16B40/20 ,  G06N10/60

Abstract: Exemplary embodiments relate to a protein engineering pipeline configured to optimize or improve proteins for specified functions. The problem space of such a task can grow quickly based on the sequence of the protein being optimized and the functions for which the protein is being designed. The solutions described herein allow the problem space to be efficiently searched by applying a combination of a protein design pipeline and an evaluation procedure performed on a quantum computer. As a result, single or multiple amino acid substitutions at a site of interest may be predicted in order to generate optimized protein variants.