公开(公告)号：US12157716B2

公开(公告)日：2024-12-03

申请号：US17259538

申请日：2019-07-09

Applicant: BASF SE

Inventor： Barbara Winkler ,  Levente Simon

IPC: C07C253/34 ,  A61K8/02 ,  A61K8/44 ,  A61Q17/04

Abstract: The present invention relates to a process for preparing a crystalline merocyanine compound, comprising the step of dissolving a merocyanine compound in an organic, polar solvent, wherein the process is performed at a pH below than 7 in the presence of an acid, wherein residual levels of colored impurities are eliminated.

公开(公告)号：US20210323912A1

公开(公告)日：2021-10-21

申请号：US17259538

申请日：2019-07-09

Applicant: BASF SE

Inventor： Barbara Winkler ,  Levente Simon

IPC: C07C253/34 ,  A61K8/44 ,  A61Q17/04 ,  A61K8/02

Abstract: The present invention relates to a process for preparing a crystalline merocyanine compound, comprising the step of dissolving a merocyanine compound in an organic, polar solvent, wherein the process is performed at a pH below than 7 in the presence of an acid, wherein residual levels of colored impurities are eliminated.