公开(公告)号：US09493491B2

公开(公告)日：2016-11-15

申请号：US15148430

申请日：2016-05-06

Applicant: BASF SE

Inventor： Oliver Huttenloch ,  Patrick Deck ,  Holger Ganz ,  Michael Mauss ,  Wolfgang Körnig ,  Michael Bock

IPC: C07B63/00 ,  C07F9/22

CPC classification number: C07F9/224 ,  C07B63/00

Abstract: A process for the removal of acids from reaction mixtures, comprising at least one product of value which is sparingly soluble in water, by at least one unpolar amine as an auxiliary base, which includes: a) reacting the auxiliary base with the acid with formation of a salt; b) reacting the salt formed in step a) with a further base which accepts the acid with liberation of the auxiliary base and combines with the acid to be accepted from the auxiliary base to form a salt which is very readily soluble in water; c) extraction of the mixture obtained in step b) with water or an aqueous medium, wherein the salt of the further base dissolves in the aqueous phase and the product of value, or the solution of the product of value, in a suitable solvent and the auxiliary base form at least one separate nonaqueous phase; and d) removal by distillation of at least part of any solvent present from the at least one nonaqueous phase obtained in step c), to form two nonmiscible liquid phases.

Abstract translation: 通过至少一种非极性胺作为辅助碱，从反应混合物中除去酸的方法，该方法包括至少一种价值小于水的产物，其包括：a）使辅助碱与酸形成反应 的盐 b）使步骤a）中形成的盐与另外的碱反应，其另外的碱可以通过辅助碱的释放与酸接触，并与待辅助的酸结合，形成非常容易溶于水的盐; c）用水或水性介质萃取步骤b）中得到的混合物，其中另外碱的盐溶解在水相中，并且将有价值的产物或产品的溶液在合适的溶剂中溶解， 辅助碱形成至少一个单独的非水相; 和d）通过蒸馏除去存在于步骤c）中获得的至少一种非水相中的任何溶剂的至少一部分，以形成两个不可混溶的液相。