公开(公告)号：US20140356916A1

公开(公告)日：2014-12-04

申请号：US14365660

申请日：2012-12-14

Applicant: BASF SE

Inventor： Christoph Wittmann ,  Stefanie Kind ,  Judith Becker

IPC: C12P13/08 ,  C12P13/00

CPC classification number: C12P13/08 ,  C12N9/93 ,  C12P13/001 ,  C12Y602/01004 ,  C12Y602/01005 ,  Y02P20/52

Abstract: Recombinant microorganisms with deregulated succinyl-CoA synthetase activity, as well as the uses for producing lysine, β-lysine, cadaverine or N-acetylcadaverine thereby are provided. Recombinant polypeptides comprising an amino acid sequence being at least 80% identical to SEQ ID NO: 51 or 53 are also provided. The method of producing fine chemicals using said recombinant microorganisms, in particular the method of producing lysine, or derivatives thereof, such as β-lysine, cadaverine or N-acetylcadaverine is further provided.

Abstract translation: 提供了具有失控的琥珀酰-CoA合成酶活性的重组微生物，以及用于产生赖氨酸，赖氨酸，尸胺或N-乙酰胆碱酯酶的用途。 还提供了包含与SEQ ID NO：51或53至少80％相同的氨基酸序列的重组多肽。 进一步提供使用所述重组微生物生产精细化学品的方法，特别是生产赖氨酸的方法或其衍生物，例如β-赖氨酸，尸胺或N-乙酰基尸胺。

公开(公告)号：US09644220B2

公开(公告)日：2017-05-09

申请号：US14365660

申请日：2012-12-14

Applicant: BASF SE

Inventor： Christoph Wittmann ,  Stefanie Kind ,  Judith Becker

IPC: C12P13/08 ,  C12P13/00 ,  C12N9/00

CPC classification number: C12P13/08 ,  C12N9/93 ,  C12P13/001 ,  C12Y602/01004 ,  C12Y602/01005 ,  Y02P20/52

Abstract: Recombinant microorganisms with deregulated succinyl-CoA synthetase activity, as well as the uses for producing lysine, β-lysine, cadaverine or N-acetylcadaverine thereby are provided. Recombinant polypeptides comprising an amino acid sequence being at least 80% identical to SEQ ID NO: 51 or 53 are also provided. The method of producing fine chemicals using said recombinant microorganisms, in particular the method of producing lysine, or derivatives thereof, such as β-lysine, cadaverine or N-acetylcadaverine is further provided.