公开(公告)号：US20180244799A1

公开(公告)日：2018-08-30

申请号：US15908705

申请日：2018-02-28

申请人： BAYER HEALTHCARE LLC

发明人： Ye JIN ,  John E. MURPHY ,  Terry HERMISTON ,  Timothy MYLES ,  Frank DITTMER ,  Michael STRERATH ,  Uwe GRITZAN

IPC分类号： C07K16/36 ,  A61K38/48 ,  A61K45/06 ,  C07K16/18 ,  C07K16/38

CPC分类号： C07K16/36 ,  A61K38/4846 ,  A61K45/06 ,  C07K16/18 ,  C07K16/38 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565

摘要： This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.