公开(公告)号：US20230167101A1

公开(公告)日：2023-06-01

申请号：US17918074

申请日：2021-04-08

申请人： BAYLOR COLLEGE OF MEDICINE

发明人： Yongcheng Song ,  Fangrui Wu ,  Shenyou Nie ,  Yuanda Hua ,  Yi-Lun Lin ,  Salma Kaochar ,  Nicholas Mitsiades

IPC分类号： C07D409/12 ,  A61P35/00 ,  C07D405/14 ,  C07D409/14 ,  C07D333/20 ,  C07D405/12 ,  C07D417/12

CPC分类号： C07D409/12 ,  A61P35/00 ,  C07D333/20 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12

摘要： Embodiments of the present disclosure pertain to compositions that include a compound that inhibits the histone acetyl transferase activity of a protein, such as p300 and/or CBP. Further embodiments of the present disclosure pertain to methods of inhibiting the histone acetyl transferase activity of a protein by exposing the protein to a composition that contains one or more of the compounds of the present disclosure. The compositions of the present disclosure may be exposed to a protein in vitro or in vivo. Additional embodiments of the present disclosure pertain to methods of treating a cancer in a subject by administering a composition of the present disclosure to the subject in order to treat the cancer.