公开(公告)号：US20190316207A1

公开(公告)日：2019-10-17

申请号：US16372747

申请日：2019-04-02

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Ajay Goel ,  Lucia Perez-Carbonell ,  C. Richard Boland

IPC: C12Q1/6886 ,  G16H10/60 ,  C12N15/113 ,  A61K31/513 ,  G16H40/63

Abstract: Embodiments provide methods and compositions related to determining treatments for colorectal cancer patients by detection and analysis of the expression level of miRNA such as miR-320e in the patients.

公开(公告)号：US10260105B2

公开(公告)日：2019-04-16

申请号：US15120052

申请日：2015-02-18

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Ajay Goel ,  Lucia Perez-Carbonell ,  C. Richard Boland

IPC: C12Q1/68 ,  A61K31/513 ,  C12N15/113 ,  G06F19/00 ,  C12Q1/6886 ,  G16H40/63 ,  G16H10/60

Abstract: Embodiments provide methods and compositions related to determining treatments for colorectal cancer patients by detection and analysis of the expression level of miRNA such as miR-320e in the patients. Embodiments provide predictive, prognostic and/or diagnostics methods by identifying miRNAs that are useful for clinical management of cancer patients, particularly colorectal cancer patients or patients at risk or determined to have colorectal cancer. Methods and compositions are based, in part, on the discovery that expression of certain miRNAs in cancer patients is associated with advancing cancer stages and/or can predict the responsiveness of cancer therapy, and can, therefore, provide basis for designing treatment strategies. In particular embodiments, the miRNA molecule is miR-320, particularly miR-320e.