公开(公告)号：US11618926B2

公开(公告)日：2023-04-04

申请号：US16489597

申请日：2018-02-28

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Ajay Goel ,  Raju Kandimalla ,  Shusuke Toden ,  Roshni Roy ,  Tsuyoshi Ozawa ,  Takatoshi Matsuyama ,  Wenhao Weng

IPC: C12Q1/6886

Abstract: Dysregulated expression of microRNAs (miRNAs) has emerged as a hallmark feature in human cancers. Aspects of the disclosure relate to methods for selecting optimal therapy for a patient from several alternative treatment options. A major clinical challenge in cancer treatment is to identify the subset of patients who will benefit from a therapeutic regimen, both in metastatic and adjuvant settings. The number of anti-cancer drugs and multi-drug combinations has increased substantially in the past decade, however, treatments continue to be applied empirically using a trial-and-error approach. Here methods and compositions are provided to determine the optimal treatment option for cancer patients.