公开(公告)号：US20250092387A1

公开(公告)日：2025-03-20

申请号：US18968907

申请日：2024-12-04

Applicant: BEIJING BAIDU NETCOM SCIENCE TECHNOLOGY CO., LTD.

Inventor： Yang LIU ,  Xiaomin FANG ,  Jie GAO ,  Xiaonan ZHANG ,  Jingzhou HE

IPC: C12N15/10

Abstract: A method and an apparatus for optimizing an mRNA sequence, an mRNA molecule, a pharmaceutical composition, and a use thereof are provided. The disclosure relates to the technical field of artificial intelligence, specifically to technical fields such as biological computing. The method for optimizing the mRNA sequence include: obtaining a first mRNA sequence for synthesizing a protein of interest, where the first mRNA sequence includes a 5′ untranslated region sequence and a coding region sequence; and adjusting the 5′ untranslated region sequence and the coding region sequence with the goal of maximizing a first score of the first mRNA sequence, so as to obtain an optimized second mRNA sequence for synthesizing the protein of interest, where the first score reflects at least one of the following indicators of the first mRNA sequence: translation initiation efficiency, codon adaptation index, and minimum free energy.