公开(公告)号：US20180051036A1

公开(公告)日：2018-02-22

申请号：US15799315

申请日：2017-10-31

申请人： BEIJING HANMI PHARMACEUTICAL CO., LTD.

发明人： Jinming LIU ,  Mi Young CHA ,  Gong LI ,  Zhanmei LI ,  Hongjuan QIU ,  Maengsup KIM

IPC分类号： C07D495/04 ,  C07D519/00 ,  C07D491/048 ,  C07D487/04 ,  A61K31/5377 ,  A61K31/53 ,  A61K45/06 ,  A61K31/519

CPC分类号： C07D495/04 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61K45/06 ,  C07D487/04 ,  C07D491/048 ,  C07D519/00 ,  A61K2300/00

摘要： The present invention relates to a compound inhibiting the activities of Bruton's tyrosine kinase (BTK) and/or Janus kinase 3 (JAK3), a pharmaceutical composition of the compound, pharmaceutical applications of same, a method for using the compound in inhibiting the activities of BTK and/or JAK3, and a method for using the compound in treatment and/or prevention of BTK- and/or JAK3-mediated diseases or disorders in mammals (especially human). The compound is as represented by structural formula (I).