公开(公告)号：US20240094223A1

公开(公告)日：2024-03-21

申请号：US18502243

申请日：2023-11-06

Applicant: BIO-RAD EUROPE GMBH ,  BIO-RAD LABORATORIES, INC.

Inventor： ISABELLE BATXELLI-MOLINA ,  FLORIAN SALIPANTE ,  ROGER P. WALKER ,  JOHN FLANAGAN ,  JEANNETTE FAREH-MICHIEL

IPC: G01N33/68 ,  G16B25/10

CPC classification number: G01N33/6893 ,  G01N33/6869 ,  G16B25/10 ,  G01N2333/521 ,  G01N2333/5421 ,  G01N2333/575 ,  G01N2400/40 ,  G01N2800/085

Abstract: The invention provides a method of diagnosing Non-Alcoholic Steatohepatitis (NASH) and/or the hepatic fibrosis status of a subject, especially a subject afflicted with Non-alcoholic fatty liver disease (NAFLD) or NASH, based on the level of only three or more particular biomarkers. The invention further provides a kit suitable for performing said method and the use of said method and methods of treating patients diagnosed in accordance with the disclosed methods.

公开(公告)号：US20220326240A1

公开(公告)日：2022-10-13

申请号：US17715988

申请日：2022-04-08

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： RAVI KAUL ,  SHUXIA ZHOU ,  ROGER P. WALKER

IPC: G01N33/569 ,  G01N33/573 ,  G01N33/62 ,  G01N33/533 ,  G01N1/40

Abstract: The present disclosure relates to the development of novel immunoassays for the detection of SARS-CoV-2 or secreted spike protein (or fragments thereof) in saliva, nasal mucosal sample, throat samples, or nasopharyngeal samples.

公开(公告)号：US20200249242A1

公开(公告)日：2020-08-06

申请号：US16632404

申请日：2018-07-19

Applicant: BIO-RAD EUROPE GMBH ,  BIO-RAD LABORATORIES, INC.

Inventor： ISABELLE BATXELLI-MOLINA ,  FLORIAN SALIPANTE ,  ROGER P. WALKER ,  JOHN FLANAGAN ,  JEANNETTE FAREH-MICHIEL

IPC: G01N33/68 ,  G16B25/10

Abstract: The invention provides a method of diagnosing Non-Alcoholic Steatohepatitis (NASH) and/or the hepatic fibrosis status of a subject, especially a subject afflicted with Non-alcoholic fatty liver disease (NAFLD) or NASH, based on the level of only three or more particular biomarkers. The invention further provides a kit suitable for performing said method and the use of said method and methods of treating patients diagnosed in accordance with the disclosed methods.

公开(公告)号：US20220018838A1

公开(公告)日：2022-01-20

申请号：US17379193

申请日：2021-07-19

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： QIAN GAO ,  RAVI KAUL ,  SHUXIA ZHOU ,  ROGER P. WALKER

IPC: G01N33/569 ,  G01N21/64

Abstract: The present invention relates to the development of novel immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples. Novel multiplex and singleplex immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples are also provided.

公开(公告)号：US20210349105A1

公开(公告)日：2021-11-11

申请号：US17314376

申请日：2021-05-07

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： ROGER P. WALKER ,  HEIDI SCHOLZ

IPC: G01N33/68 ,  G01N33/569 ,  G01N33/533

Abstract: The present disclosure relates to the development of novel immunoassays for the detection of SARS-CoV-2 antigens and/or SARS-CoV-2 specific antibodies and, optionally, one or more cytokine in patient samples.