公开(公告)号：US20140163100A1

公开(公告)日：2014-06-12

申请号：US14119373

申请日：2012-05-25

Applicant: BIOGEN IDEC MA INC.

Inventor： Katherine Dawson ,  Gilmore O'Neill ,  Alfred Sandrock

IPC: A61K31/225

CPC classification number: A61K31/225 ,  A61K31/194

Abstract: Methods of treating multiple sclerosis in a subject, including: reducing the frequency of relapse, reducing the annualized relapse rate, reducing the risk of disability progression, reducing the number of new or newly enlarging T2 lesions, reducing the number of gadolinium lesions; and methods of preserving/increasing myelin content in a subject having multiple sclerosis; by daily administering a composition containing a fumarate, such as dimethyl fumarate or monomethyl fumarate, to the subject.

Abstract translation: 治疗多发性硬化症的方法包括：减少复发频率，降低年复发率，降低残疾进展的风险，减少新增或新扩大的T2病变数量，减少钆损伤数量; 以及在具有多发性硬化症的受试者中保存/增加髓磷脂含量的方法; 通过每天施用含有富马酸盐的富马酸盐的组合物，例如富马酸二甲酯或富马酸单甲酯。