公开(公告)号：US20140079716A1

公开(公告)日：2014-03-20

申请号：US13830500

申请日：2013-03-14

Applicant: BIOGEN IDEC MA INC.

Inventor： Ann M. RANGER ,  Ellen GARBER ,  Justin A. CARAVELLA ,  Alexey A. LUGOVSKOY ,  Joseph ARNDT ,  Frederick R. TAYLOR ,  Giovanna ANTOGNETTI ,  Eric DAY

IPC: C07K14/525

CPC classification number: C07K14/5255 ,  A61K2039/505 ,  C07K16/242 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The instant invention is based, at least in part on the identification of a new class of antibodies that result, e.g., in improved LT blocking capabilities. Methods of making the subject binding molecules and methods of using the binding molecules of the invention to antagonize LTβR signaling are also provided.

Abstract translation: 本发明至少部分地基于导致例如改进的LT阻断能力的新类型的抗体的鉴定。 还提供了制备受试者结合分子的方法和使用本发明的结合分子拮抗LT＆bgr R信号的方法。