公开(公告)号：US20210188809A1

公开(公告)日：2021-06-24

申请号：US16071200

申请日：2017-01-18

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffrey Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph P. Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield ,  Nathan Genung

IPC: C07D401/14 ,  A61K45/06

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.

公开(公告)号：US10577367B2

公开(公告)日：2020-03-03

申请号：US16271497

申请日：2019-02-08

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffery Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield

IPC: C07D401/14 ,  C07D487/04 ,  A61K31/416 ,  A61K31/437 ,  A61K31/44 ,  A61P13/12 ,  A61P19/02 ,  C07D471/04 ,  C07D405/14 ,  C07D413/14 ,  C07B59/00 ,  C07D401/12 ,  C07D417/14

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20170354639A1

公开(公告)日：2017-12-14

申请号：US15521239

申请日：2015-10-23

Applicant: Biogen MA Inc.

Inventor： Jianhua Chao ,  Brian Lucas

IPC: A61K31/365 ,  C07D413/06 ,  A61K31/423 ,  C07D407/06 ,  C07D411/06 ,  A61K31/39 ,  C07D307/60

CPC classification number: A61K31/365 ,  A61K31/39 ,  A61K31/423 ,  C07D307/58 ,  C07D307/60 ,  C07D407/06 ,  C07D411/06 ,  C07D413/06

Abstract: Provided herein are compounds of formula (I) and compositions containing the compounds. The compounds and compositions are useful in the methods of treating, amelioration or prophylaxix of diseases associated with Nrf2/NF-κB pathways. The diseases associated include, but are not limited to a fibrotic disease such as lung fibrosis, liver fibrosis, kidney fibrosis, and scleroderma, or a neurodegenerative disease, such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, and Alzheimer's disease, and sickle cell disease.

公开(公告)号：US11427561B2

公开(公告)日：2022-08-30

申请号：US16071200

申请日：2017-01-18

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin M. Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffrey Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph P. Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield ,  Nathan Genung

IPC: C07D401/14 ,  A61K45/06

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.

公开(公告)号：US20170204093A1

公开(公告)日：2017-07-20

申请号：US15326740

申请日：2015-07-17

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffery Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield

IPC: C07D471/04 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07B59/00 ,  C07D401/14 ,  C07D417/14

CPC classification number: C07D471/04 ,  A61K31/416 ,  A61P13/12 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20190248787A1

公开(公告)日：2019-08-15

申请号：US16271497

申请日：2019-02-08

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffery Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield

IPC: C07D471/04 ,  C07D417/14 ,  C07D413/14 ,  A61K31/416 ,  C07D401/12 ,  C07B59/00 ,  C07D405/14 ,  C07D401/14

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US10246456B2

公开(公告)日：2019-04-02

申请号：US15326740

申请日：2015-07-17

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffery Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield

IPC: C07D471/04 ,  C07D413/14 ,  C07D405/14 ,  C07D401/14 ,  A61K31/416 ,  A61P13/12 ,  C07B59/00 ,  C07D401/12 ,  C07D417/14

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.