公开(公告)号：US20160318935A1

公开(公告)日：2016-11-03

申请号：US15103756

申请日：2014-12-11

Applicant: BIOGEN MA INC. ,  SUNESIS PHARMACEUTICALS, INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Gnanasambandam Kumaravel ,  Hua Miao ,  Andrea Bertolotti-Ciarlet ,  Kevin Otipoby

IPC: C07D487/04 ,  G01N33/573 ,  C07D513/04 ,  C07D473/00 ,  C07D519/00 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D473/00 ,  C07D513/04 ,  C07D519/00 ,  G01N33/573 ,  G01N2333/9121

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract translation: 本发明提供了可用作Bruton酪氨酸激酶抑制剂的化合物及其组合物，其表现出所需特性。

公开(公告)号：US10280169B2

公开(公告)日：2019-05-07

申请号：US15103756

申请日：2014-12-11

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Gnanasambandam Kumaravel ,  Hua Miao ,  Andrea Bertolotti-Ciarlet ,  Kevin Otipoby

IPC: C07D487/04 ,  C07D473/00 ,  A61K31/519 ,  A61K31/522 ,  C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  G01N33/573

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.