公开(公告)号：US20150299323A1

公开(公告)日：2015-10-22

申请号：US14597262

申请日：2015-01-15

Applicant: BIOGEN MA INC.

Inventor： Michael Karpusas ,  Paul D. Lyne ,  Ellen A. Garber Stark ,  Jose William Saldanha

IPC: C07K16/28

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  Y02A90/26

Abstract: Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.

公开(公告)号：US10336826B2

公开(公告)日：2019-07-02

申请号：US15470442

申请日：2017-03-27

Applicant: BIOGEN MA INC.

Inventor： Michael Karpusas ,  Paul D. Lyne ,  Ellen A. Garber Stark ,  Jose William Saldanha

IPC: A61K39/395 ,  C07K16/28 ,  A61K39/00

Abstract: Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.

公开(公告)号：US20170335000A1

公开(公告)日：2017-11-23

申请号：US15470442

申请日：2017-03-27

Applicant: BIOGEN MA INC.

Inventor： Michael Karpusas ,  Paul D. Lyne ,  Ellen A. Garber Stark ,  Jose William Saldanha

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  Y02A90/26

Abstract: Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.

公开(公告)号：US09644030B2

公开(公告)日：2017-05-09

申请号：US14597262

申请日：2015-01-15

Applicant: BIOGEN MA INC.

Inventor： Michael Karpusas ,  Paul D. Lyne ,  Ellen A. Garber Stark ,  Jose William Saldanha

IPC: A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  Y02A90/26

Abstract: Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.