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公开(公告)号：US20230089374A1
公开(公告)日：2023-03-23
申请号：US17751144
申请日：2022-05-23
IPC分类号： C07D249/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
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公开(公告)号：US20230079913A1
公开(公告)日：2023-03-16
申请号：US17751136
申请日：2022-05-23
IPC分类号： C07D249/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
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公开(公告)号：US20230088214A1
公开(公告)日：2023-03-23
申请号：US17619818
申请日：2020-06-18
发明人： Bing WANG , Brett E. CRAWFORD , Shripad BHAGWAT , Xiaomei BAI
IPC分类号： C07D417/12 , A61P13/02 , C07D249/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D401/04
摘要： Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
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公开(公告)号：US20190322676A1
公开(公告)日：2019-10-24
申请号：US16471515
申请日：2017-12-19
发明人： Bing WANG
IPC分类号： C07D487/08 , C07D487/10 , C07D451/04 , C07D211/26 , C07D207/14 , C07D211/58 , C07D487/04 , C07D409/12 , C07D241/38 , C07D405/06
摘要： Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.
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