专利检索 ap:("BIOMARIN PHARMACEUTICAL INC.") AND inv:"Roger LAWRENCE," 第 1 页

1.

发明公开
COMPOSITIONS OF BETA-HEXOSAMINIDASE VARIANTS AND USES THEREOF 审中-公开

公开(公告)号：US20240318156A1

公开(公告)日：2024-09-26

申请号：US18573298

申请日：2022-06-24

申请人： BIOMARIN PHARMACEUTICAL INC.

发明人： Daniel WENDT , Mika AOYAGI-SCHARBER , Roger LAWRENCE, , Manuel LOPEZ

IPC分类号： C12N9/24 , A61K38/00

CPC分类号： C12N9/2402 , C12Y302/01052 , A61K38/00

摘要： Disclosed herein are recombinant β-hexosaminidase variant a subunits that form a β-hexosaminidase variant a subunit homodimer that have optimized properties for use in treating Tay-Sachs disease or Sandhoff Disease.