公开(公告)号：US20230241223A1

公开(公告)日：2023-08-03

申请号：US17913743

申请日：2021-03-24

Applicant: BIONTECH SE

Inventor： Heinrich HAAS ,  Sara NOGUEIRA ,  Anne SCHLEGEL

IPC: A61K47/54 ,  A61K47/64 ,  A61K47/69 ,  A61K9/00

CPC classification number: A61K47/543 ,  A61K9/0019 ,  A61K47/646 ,  A61K47/6911 ,  A61K47/6929

Abstract: The present disclosure relates to RNA particles for delivery of RNA to target tissues after administration, in particular after parenteral administration such as intravenous, intramuscular, subcutaneous or intratumoral administration, and compositions comprising such RNA particles. The RNA particles in one embodiment comprise single-stranded RNA such as mRNA which encodes a peptide or protein of interest, such as a pharmaceutically active peptide or protein. The RNA is taken up by cells of a target tissue and the RNA is translated into the encoded peptide or protein, which may exhibit its physiological activity.