公开(公告)号：US20220144822A1

公开(公告)日：2022-05-12

申请号：US17432017

申请日：2020-03-06

Applicant: BioNTech SE

Inventor： Christophe HENRY

IPC: C07D471/04 ,  C07D215/46

Abstract: The present invention relates to a process for synthesizing N-(4-(4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl)butyl)-N-(tetrahydro-2H-pyran-4-yl)acetamide, an imidazoquinoline derivative useful as toll-like receptor agonist, in particular as an agonist of TLR7, which promotes induction of certain cytokines. Furthermore, the present invention also provides intermediates useful in the synthesis of N-(4-(4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl)butyl)-N-(tetrahydro-2H-pyran-4-yl)acetamide.

公开(公告)号：US20210002249A1

公开(公告)日：2021-01-07

申请号：US16644079

申请日：2018-08-31

Applicant: BIONTECH SE

Inventor： Christophe HENRY

IPC: C07D401/04 ,  A61P35/00

Abstract: The invention relates to imidazoquinoline derivatives and to pharmaceutical compositions containing the imidazoquinoline derivatives. The imidazoquinoline derivatives of the invention are useful as toll-like receptor agonists, in particular agonists of TLR7, and promote induction of certain cytokines.

公开(公告)号：US20220227756A1

公开(公告)日：2022-07-21

申请号：US17590550

申请日：2022-02-01

Applicant: BIONTECH SE

Inventor： Christophe HENRY

IPC: C07D471/04 ,  A61P35/00

Abstract: The invention relates to imidazoquinoline derivatives and to pharmaceutical compositions containing the imidazoquinoline derivatives. The imidazoquinoline derivatives of the invention are useful as toll-like receptor agonists, in particular agonists of TLR7, and promote induction of certain cytokines.

公开(公告)号：US20200317663A1

公开(公告)日：2020-10-08

申请号：US16644076

申请日：2018-08-31

Applicant: BIONTECH SE

Inventor： Christophe HENRY

IPC: C07D471/04 ,  A61P35/00

Abstract: The invention relates to imidazoquinoline derivatives and to pharmaceutical compositions containing the imidazoquinoline derivatives. The imidazoquinoline derivatives of the invention are useful as toll-like receptor agonists, in particular agonists of TLR7, and promote induction of certain cytokines.

公开(公告)号：US20220242845A1

公开(公告)日：2022-08-04

申请号：US17669117

申请日：2022-02-10

Applicant: BIONTECH SE

Inventor： Christophe HENRY

IPC: C07D401/04 ,  A61P35/00 ,  C07D471/04

Abstract: The invention relates to imidazoquinoline derivatives and to pharmaceutical compositions containing the imidazoquinoline derivatives. The imidazoquinoline derivatives of the invention are useful as toll-like receptor agonists, in particular agonists of TLR7, and promote induction of certain cytokines.