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公开(公告)号：US20230117803A1
公开(公告)日：2023-04-20
申请号：US17759906
申请日：2021-02-02
Applicant: BIONTECH SE
Inventor： Ugur SAHIN , Alexander MUIK , Lena KRANZ , Mathias VORMEHR
Abstract: The present disclosure relates to methods and compositions for inducing an immune response in a subject comprising providing to the subject a peptide or protein vaccine and a binding agent, such as a bispecific antibody, binding to PD-L1 and CD137, such as human PD-L1 and human CD137, e.g., by co-administering to the subject a peptide or protein used for vaccination or a polynucleotide, in particular RNA, encoding a peptide or protein used for vaccination, and a binding agent binding to PD-L1 and CD137 or a polynucleotide, in particular RNA, encoding a binding agent binding to PD-L1 and CD137. The present disclosure further relates to medical preparations useful in the methods disclosed herein.
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公开(公告)号：US20220143144A1
公开(公告)日：2022-05-12
申请号：US17442568
申请日：2020-04-02
Applicant: BIONTECH SE , TRON-Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Inventor： Ugur SAHIN , Mathias VORMEHR , Lena KRANZ , Sina FELLERMEIER-KOPF , Alexander MUIK , Daniel REIDENBACH , Mustafa DIKEN , Sebastian KREITER
Abstract: The present disclosure relates to methods and agents for enhancing the effect of immune effector cells, in particular immune effector cells that respond to interleukin-2 (IL2), for example effector T cells such as CD8+ T cells. Specifically, the present disclosure relates to methods comprising administering to a subject a polypeptide comprising IL2 or a functional variant thereof or a polynucleotide encoding a polypeptide comprising IL2 or a functional variant thereof and a polypeptide comprising type I interferon (IFN) or a functional variant thereof or a polynucleotide encoding a polypeptide comprising type I interferon or a functional variant thereof.
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