公开(公告)号：US20200299742A1

公开(公告)日：2020-09-24

申请号：US16634267

申请日：2018-07-30

Applicant: BIOPETROLIA AB

Inventor： Mingtao Huang ,  Anastasia Krivoruchko ,  Florian David ,  Jens Nielsen

IPC: C12P21/00 ,  C07K14/395

Abstract: The present invention related to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing and secreting different recombinant proteins. The improved ability is obtained by disruption in intracellular transport between the Golgi and the endosome. In particular embodiments, the disruption is achieved by downregulation or deletion of the gene encoding a Tda3p homolog. The fungal cell and method of the invention would allow for large-scale production of recombinant proteins in fungal cells.