公开(公告)号：US20250092117A1

公开(公告)日：2025-03-20

申请号：US18819571

申请日：2024-08-29

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Craig BENSON ,  Pronabesh DASMAHAPATRA ,  Suresh KATRAGADDA ,  Yunzhi LIN ,  Annemieke WILLEMZE ,  Amanda WILSON

IPC: C07K14/755 ,  A61K9/00 ,  A61K38/00 ,  A61P7/04 ,  A61P29/02 ,  C07K14/00

Abstract: The present disclosure provides a method of treating hemophilia A in a human subject in need thereof comprising administering to the subject a chimeric protein comprising (i) a factor VIII (FVIII) protein and (ii) a von Willebrand factor (VWF) fragment comprising a D′ domain of VWF and a D3 domain of VWF.